numbuzin No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate – 17g

Product
Overview

numbuzin No.5 Glutathione TXA Advanced Dark Spot Ampoule
Concentrate (17g) is a highly concentrated dual-active dark spot treatment
from numbuzin’s No.5 Vitamin line that combines glutathione — a powerful
endogenous antioxidant with multi-pathway melanin inhibition — with
tranexamic acid (TXA) — a serine protease inhibitor with specific
anti-pigmentation activity — in an ampoule concentrate format that delivers
the maximum effective concentration of both actives for the most potent,
targeted dark spot correction in the numbuzin No.5 line.

Glutathione (γ-L-glutamyl-L-cysteinyl-glycine) is the body’s most
abundant endogenous antioxidant tripeptide, produced in cells to protect
against oxidative stress. In skincare, glutathione has emerged as a
significant brightening ingredient because of its multi-pathway melanin
inhibition: it inhibits tyrosinase (reducing melanin synthesis), shifts
melanogenesis from darker eumelanin towards lighter phaeomelanin (changing
the type of melanin produced), and scavenges the free radicals and reactive
oxygen species that trigger melanocyte melanin overproduction (addressing the
upstream trigger of pigmentation). Tranexamic acid (originally a haemostatic
pharmaceutical) inhibits the plasminogen-to-plasmin conversion that
stimulates keratinocytes to release melanocyte-stimulating factors —
effectively reducing the melanocyte activation signals that drive
post-inflammatory hyperpigmentation (from acne, sun exposure, and skin
trauma). Together, these two actives address melanin production from three
independent pathways simultaneously for the most comprehensive dark spot
correction possible in a single topical ampoule treatment.

Key Benefits

• Glutathione inhibits tyrosinase and shifts melanogenesis toward
  lighter phaeomelanin for multi-pathway brightening.
• Glutathione scavenges the free radicals that trigger excess
  melanocyte melanin production for upstream protection.
• TXA inhibits plasmin-mediated melanocyte stimulation to reduce
  post-inflammatory hyperpigmentation signals.
• Ampoule concentrate format maximises active concentration for the
  most potent dark spot treatment step.
• Dual-mechanism formula addresses melanin at production, shifting,
  and stimulation levels for advanced brightening.

Key Ingredients

Glutathione (reduced form L-glutathione, or stabilised
derivatives) inhibits tyrosinase directly, shifts melanin type production
from eumelanin to phaeomelanin (lighter pigment), and scavenges ROS that
activate melanocyte melanin overproduction. Tranexamic Acid (TXA) is a
synthetic lysine derivative that inhibits plasminogen binding to
keratinocytes, reducing plasmin formation, which reduces prostaglandin E2 and
α-MSH-mediated melanocyte-stimulating signals from keratinocytes —
specifically targeting post-inflammatory hyperpigmentation
mechanisms.

Who It’s For

Ideal for those with stubborn dark spots, post-inflammatory
hyperpigmentation, melasma, or persistent uneven skin tone that has not
responded fully to simpler brightening actives like niacinamide alone. Best
for those who want a concentrated, advanced dual-mechanism dark spot ampoule
treatment. Use with strict daily SPF — sun protection is non-negotiable when
treating active hyperpigmentation to prevent UV-triggered pigmentation
recurrence.

Why Shop at Kioraa

Shop authentic numbuzin products in Bangladesh at Kioraa —
advanced K-beauty brightening actives with genuine sourcing and fast local
delivery.